Title: Coverage statistics for sequence census methods
Author: Steven N. Evans, Valerie Hower and Lior Pachter
Abstract: We study the shape of coverage functions resulting from the sequencing of random genome
fragments, and show that they can be described by Galton-Watson trees. This extends standard
analyses of shotgun sequencing that focus on coverage statistics at individual sites, and provides
a null model for detecting deviations from random coverage in high-throughput sequence census
based experiments such as ChIP-Seq.
Date: April 2010