

Stat 260, Spring 98
Statistics in Genetics
Terry Speed
(Back to list of Terry's classes)
Time: TT: 12.30-2.00
Place: 334 Evans Hall
The course will be a survey of applications of probability and statistics
to modern genetics and molecular biology. No previous acquaintance with
these areas is required, but a willingness to do collateral reading in
the field will be assumed.
Please check with me beforehand if you want to come to a specific class,
as there may be variations from this schedule. I will be forced to miss
3 classes, and these will be taken by the people named below. I hope we
can get notes Jan 20 Mendel and segregation. Jan 22
Terry Speed
327 Evans Hall
510-642-2781
terry@stat.berkeley.edu
Week 1 (notes in postscript
or html)
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Jan 20 Mendel and segregation
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Jan 22
Week 2 (notes in postscript
or html)
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Jan 27 Meiosis. Recombination.
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Jan 29
Week 3 (notes in postscript
or html)
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Feb 3 Multilocus mapping in experimental crosses.
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Feb 5
Week 4 (notes in postscript
or html)
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Feb 10 Mouse experiments : mapping genes for traits using genome-wide scans.
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Feb 12
Week 5 (notes in postscript
or html)
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Feb 17 Genetic epidemiology: Association and linkage.
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Feb 19
Week 6 (notes in postscript
or html)
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Feb 24 Affected sib-pair methods and their extensions (Sandrine Dudoit)
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Feb 26
Week 7 (notes in postscript
or pdf)
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Mar 3 Multilocus mapping in small pedigrees.
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Mar 5
Week 8 Two sets of notes for this week:
(week8a.ps,
week8a.html)
(week8b.ps,
week8b.html)
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Mar 10 Multilocus mapping in large pedigrees
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Mar 12 DNA sequencing (Jane Fridlyand)
Week 9 Two sets of notes for this week:
(week9a.ps,
week9a.html)
(week9b.ps,
week9b.html)
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Mar 17 Multilocus mapping in large pedigrees (ctd)
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Mar 19 The polymerase chain reaction.
SPRING BREAK
Week 10 (notes in postscript
or html)
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Mar 31 Clones and clone maps (Ru-Fang Yeh)
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Apr 2
Week 11 (notes in postscript
or html)
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Apr 7 Simple statistics of DNA sequences.
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Apr 9
Week 12 (notes in postscript
or html)
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Apr 14 Finding genes in DNA sequence.
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Apr 16
Week 13 Two sets of notes for this week:
(week13a.ps,
week13a.html)
(week13b.ps,
week13b.html)
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Apr 21 Molecular evolution.
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Apr 23
Week 14 (notes in postscript
or html)
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Apr 28 Sequence alignment.
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Apr 30
Week 15 Two sets of notes for this week:
(week15a.ps,
week15a.html)
(week15b.ps,
week15b.html)
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May 5 More sequence alignment.
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May 7 Database searching.
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Bonus! An Heuristic Proof of the Karlin-Altschul Theorem in postscript
or html