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Finding an admissible starting genetic state X

 

MCMC guarantees that the sampled genetic states X have positive probability under , but we still need to find an admissible state to start from. This may be difficult if the space of admissible X is severely restricted by the data Y. Ideally, we would also like to start near a major mode of the distribution, to avoid that the sampler spends a long time in low probability regions at the beginning of the simulation. The most recent approaches to finding initial configurations use reverse peeling on parts of the pedigree where it is simple to do, and simulation from approximate genotype distributions elsewhere (Heath [3]).



Simon Cawley
Wed Apr 22 19:50:08 PDT 1998