The HIV/AIDS pandemic has generated multiple paradoxes: ethical, political, and cultural. This talk explores the systematic "misconceptions" that the international AIDS establishment has generated and the culture that makes some AIDS interventions prosper while others languish (hint: neither religious fundamentalism nor scientific evidence plays a decisive role). I then explore the paradox of AIDS prevention in Botswana versus Uganda. Despite Botswana's stable, capable government and strong commitment to AIDS prevention, its prevention efforts failed, while Uganda, with a history of political instability, an administratively weaker government, and much less health infrastructure was able dramatically to lower HIV prevalence.