Annette's research interests include survival analysis, regression trees, genomics, array Comparative Genomic Hybridization (CGH) analysis, linking clinical outcomes to biological covariates, and competing risks.

Annette's dissertation, Novel Approaches to Prediction of Survival in Cancer Research: Focus in Genomics, involves a generalization of regression trees for censored data, a new algorithm for splitting a high-dimensional covariate space for the purposes of prediction with censored data, and a novel approach to estimating absolute risk in nested case-control studies. All three projects incorporate the estimating equation methodology of van der Laan and Robins (2003).

Publications in Peer Reviewed Journals:

Molinaro A, van der Laan MJ , Moore DH, and Kerlikowske K. Survival Point Estimate Prediction in Cohorts with Nested Case-Control Study Designs. Submitted to Statistics in Medicine. Technical Report

Molinaro A, Dudoit S, and van der Laan M. Tree-based multivariate regression and density estimation with right-censored data. Special Issue on Multivariate Methods in Genomic Data Analysis Genomics, Journal of Multivariate Analysis 90(1):154-177, 2004. Abstract Code and Functions

Kerlikowske K, Molinaro A, Cha I, Ljung BM, Ernster V, Stewart K, Chew K, Moore D, and Waldman F. Predictors of Recurrence Among Women with DCIS Treated by Lumpectomy. Journal of National Cancer Institute 95(22): 1692-1702, 2003. Abstract

Dudoit S, van der Laan M, Keles S, Molinaro A, Sinisi S, and Teng SL. Loss-based estimation with cross-validation: Applications to microarray data analysis and motif finding. SIGKDD Explorations 5(2): 37-49, 2003.

Aust DE, Terdiman JP, Willenbucher RF, Chang CG, Molinaro A, Baretton GB, Loehrs U, and Waldman FM. The apc/beta-catenin pathway in ulcerative colitis-related colorectal carcinomas: A mutational analysis. Cancer 94(5):1421-7, 2002.

Etzell JE, Devries S, Chew K, Florendo C, Molinaro A, Ljung BM, and Waldman FM. Loss of chromosome 16q in lobular carcinoma in situ. Human Pathology 32: 292-6, 2001.

Aust DE, Terdiman JP, Willenbucher RF, Chew K, Ferrell L, Florendo C, Molinaro AM, Baretton GB, Loehrs U, Waldman, FM. Altered Distribution of beta-catenin, and its binding proteins E-cadherin and APC, in Ulcerative Colitis-Related Colorectal Cancers . Modern Pathology 14: 29-39, 2001.

Aust DE, Willenbucher RF, Terdiman JP, Ferrell LD, Chang CG, Moore DH, Molinaro AM, Baretton GB, Loehrs U, Waldman FM. Chromosomal Alterations in Ulcerative Colitis-Related and Sporadic Colorectal Cancers by Comparative Genomic Hybridization. Human Pathology 31(1): 109-114, 2000.

Technical Reports:

Molinaro A and van der Laan M. A Deletion/Substitution/Addition algorithm for partitioning the covariate space in prediction. Technical Report 162, Division of Biostatistics, University of California, Berkeley, 2004. www.bepress.com/ucbbiostat/paper162

Molinaro A, van der Laan MJ , Moore DH, and Kerlikowske K. Survival Point Estimate Prediction in Cohorts with Nested Case-Control Study Designs. Technical Report 149, Division of Biostatistics, University of California, Berkeley, 2004. www.bepress.com/ucbbiostat/paper149

Molinaro A, Dudoit S, and van der Laan M. Tree-based multivariate regression and density estimation with right-censored data. Technical Report 135, Division of Biostatistics, University of California, Berkeley, 2003. www.bepress.com/ucbbiostat/paper135 Code and Functions

Molinaro A, van der Laan M, and Moore D. Comparative genomic hybridization array analysis. Technical Report 106, Division of Biostatistics, University of California, Berkeley, 2002. www.bepress.com/ucbbiostat/paper106.

Other Manuscripts:

Molinaro AM and van der Laan M (2004), A New Partitioning Algorithm for Prediction of Survival Outcomes: Illustration with Histogram Regression, 2004 Proceedings of the American Statistical Association, Statistical Computing Section[CD-ROM], Alexandria, VA: American Statistical Association.

Presentations:

Subsetting and Clustering of array Comparative Genomic Hybridization Data

Institute for Scientific Computing Research Seminar, Lawrence Livermore National Laboratory, December, 2001. Invited.

Prediction of Survival with Regression Trees and Cross Validation

Biostatistics Core Meeting, University of California, San Francisco Comprehensive Cancer Center, June, 2003. Invited.

Graybill Conference on Microarrays, Bioinformatics, and Related Topics, Colorado State University, June, 2003. Contributed.

Prediction of Survival with Piecewise Constant Regression and Cross Validation

International Conference on Statistics, Combinatorics and Related Areas, University of Southern Maine, Oct, 2003. Invited.

Biostatistics Seminar, University of California, Los Angeles, October, 2003. Invited.

School of Natural Sciences Seminar, University of California, Merced, November, 2003. Invited.

Piecewise Constant Estimation in Prediction of Survival Outcomes: Applications in Genomics

Biostatistics Seminar, Boston University, January, 2004. Invited.

Biostatistics Seminar, Emory University, January, 2004. Invited.

Biostatistics Seminar, Yale University, February, 2004. Invited.

Statistics and Genomics Seminar, University of California, Berkeley, February, 2004. Invited.

Bioinformatics Seminar, University of California, Davis, February, 2004. Invited.

Biostatistics Seminar, Wake Forest University, February, 2004. Invited.

Biostatistics Seminar, University of Pennsylvania, February, 2004. Invited.

Biostatistics Seminar, The Fred Hutchinson Cancer Center, March, 2004. Invited.

Biostatistics Seminar, University of Washington, March, 2004. Invited.

International Conference on Analysis of Genomic Data, Harvard Medical School, May 2004. Contributed.

Joint Statistical Meetings, Toronto, Canada, August 2004. Contributed.

Biostatistics Branch Seminar, Division of Cancer Epidemiology and Genetics, National Cancer Institute, September 2004. Invited.

Workshops and Colloquiums:

Statistical Science for Genome Biology, Banff, Canada, August 2004. Invited participant.

3rd Annual Cancer Prevention Fellows' Scientific Symposium, National Institutes of Health, Bethesda, MD, September 2004. Invited poster.